Yamaha's new n12 is a marvel of modern recording technology. Not only is it a full-function mixer, but it's also an integrated interface for Cubase. Onboard there are eight pristine Yamaha preamps, 3-band EQ, morph-able compressor, and a FireWire connection to the computer.
The audio passes through the n12 - which allows you to manipulate signal as you would on a conventional mixer including setting up monitor mixes for the performers - and then straight into Cubase. The n12 is the future of audio interfaces!